Cardiovascular Physiology and Pathophysiology

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Selected Publications

Hennis K, Piantoni C, Biel M, Fenske S, Wahl-Schott C. Pacemaker Channels and the Chronotropic Response in Health and Disease.
Circulation Research (2024). PMID: 38723033

Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.
Nature Immunology (2023). PMID: 37903858

Hennis K, Rötzer RD, Rilling J, Wu Y, Thalhammer SB, Biel M, Wahl-Schott C, Fenske S. In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability.
Nature Protocols (2022). PMID: 35314849

Drakhlis L, Biswanath S, Farr C, Lupanow V, Teske J, Ritzenhoff K, Franke A, Manstein F, Bolesani E, Kempf H, Liebscher S, Schenke-Layland K, Hegermann J, Nolte L, Meyer H, de la Roche J, Thiemann S, Wahl-Schott C, Martin U, Zweigerdt R. Human heart-forming organoids recapitulate early heart and foregut development.
Nature Biotechnology (2021). PMID: 33558697

Fenske S, Hennis K, Rötzer RD, Brox VF, Becirovic E, Scharr A, Gruner C, Ziegler T, Mehlfeld V, Brennan J, Efimov IR, Pauza AG, Moser M, Wotjak CT, Kupatt C, Gönner R, Zhang R, Zhang H, Zong X, Biel M, Wahl-Schott C. cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.
Nature Communications (2020). PMID: 33144559

Chen CC, Cang C, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C. Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.
Nature Protocols (2017). PMID: 28726848

Fenske S, Pröbstle R, Auer F, Hassan S, Marks V, Pauza DH, Biel M, Wahl-Schott C. Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
Nature Protocols (2016). PMID: 26658468

Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.
Science (2015). PMID: 25722412

Fenske S, Krause SC, Hassan S, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott C. Sick sinus syndrome in HCN1-deficient mice.
Circulation (2013). PMID: 24218458

Direnberger S, Mues M, Micale V, Wotjak CT, Dietzel S, Schubert M, Scharr A, Hassan S, Wahl-Schott C, Biel M, Krishnamoorthy G, Griesbeck O. Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model.
Nature Communications (2012). PMID: 22929788

Fenske S, Mader R, Scharr A, Paparizos C, Cao-Ehlker X, Michalakis S, Shaltiel L, Weidinger M, Stieber J, Feil S, Feil R, Hofmann F, Wahl-Schott C, Biel M. HCN3 contributes to the ventricular action potential waveform in the murine heart.
Circulation Research (2011). PMID: 21903939