Recent Publications

2024

Hennis K, Piantoni C, Biel M, Fenske S, Wahl-Schott C. Pacemaker Channels and the Chronotropic Response in Health and Disease. Circ Res. 2024 May 10;134(10):1348-1378. doi: 10.1161/CIRCRESAHA.123.323250. Epub 2024 May 9. PMID: 38723033.

Arribas V, Onetti Y, Ramiro-Pareta M, Villacampa P, Beck H, Alberola M, Esteve-Codina A, Merkel A, Sperandio M, Martínez-Estrada OM, Schmid B, Montanez E. Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation. JCI Insight.
2024 Feb 1:e177819. doi: 10.1172/jci.insight.177819. Epub ahead of print. PMID:38300714.

Azubuike-Osu SO, Kuhs A, Götz P, Faro A, Preissner KT, Arnholdt C, Deindl E. Treatment with Cobra Venom Factor Decreases Ischemic Tissue Damage in Mice. Biomedicines. 2024; 12(2):309. https://doi.org/10.3390/biomedicines12020309

Seizer P, von Ungern-Sternberg SNI, Haug V, Dicenta V, Rosa A, Butt E, Nöthel M, Rohlfing AK, Sigle M, Nawroth PP, Nussbaum C, Sperandio M, Kusch C, Meub M, Sauer M, Münzer P, Bieber K, Stanger A, Mack AF, Huber R, Brand K, Lehners M, Feil R, Poso A, Krutzke K, Schäffer TE, Nieswandt B, Borst O, May AE, Zernecke A, Gawaz M, Heinzmann D. Cyclophilin A is a ligand for RAGE in thrombo- inflammation. Cardiovasc Res. 2024 Jan 4:cvad189. doi:
10.1093/cvr/cvad189. Epub ahead of print. PMID: 38175781.

2023

Maier-Begandt D, Alonso-Gonzalez N, Klotz L, Erpenbeck L, Jablonska J, Immler R, Hasenberg A, Mueller TT, Herrero-Cervera A, Aranda-Pardos I, Flora K, Zarbock A, Brandau S, Schulz C, Soehnlein O, Steiger S; TRR332 consortium. Neutrophils - Biology and Diversity. Nephrol Dial Transplant. 2023 Dec 19:gfad266. doi: 10.1093/ndt/gfad266. Epub ahead of print. PMID: 38115607.

Kroll J, Hauschild R, Kuznetcov A, Stefanowski K, Hermann MD, Merrin J, Shafeek L, Müller-Taubenberger A, Renkawitz J. Adaptive pathfinding by nucleokinesis during amoeboid migration. EMBO J. 2023 Dec 11;42(24):e114557. doi: 10.15252/embj.2023114557. Epub 2023 Nov 21. PMID: 37987147; PMCID: PMC10711653.

Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nat Immunol. 2023 Dec;24(12):2021-2031. doi: 10.1038/s41590-023-01656-1. Epub 2023 Oct 30. PMID: 37903858; PMCID: PMC10681899.

Baeumler P, Brenske A, Winkelmann A, Irnich D, Averbeck B. Strong and aversive cold processing and pain facilitation in fibromyalgia patients relates to augmented thermal grill illusion. Sci Rep. 2023 Sep 13:159822. doi: 10.1038/s41598-023-42288-7. PMID: 37749154

Yang WH, Aziz PV, Heithoff DM, Kim Y, Ko JY, Cho JW, Mahan MJ, Sperandio M, Marth JD. Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis. iScience. 2023 Sep 9;26(10):107883. doi: 10.1016/j.isci.2023.107883. PMID: 37752945; PMCID: PMC10518488.

Zubieta-DeUrioste N, Arias-Reyes C, Sanchez L, Armijo-Subieta NF, Merino-Luna A, Solarte I, Escalante-Kanashiro R,Carmona-Suazo JA, Poma EM, Jimenez-Aguilar R, Calle-Aracena JM, Lopez-Bascope A, Vera R, Zubieta-DeUrioste R, Rossel N, Peña-Y-Lilio Y,Chambi-Quilla G, Herrera-Leon L, Garrido-Salazar S, Cordova FNV, Coronel FVM, Deindl E, Sheldon R, Accinelli RA, Schneider-Gasser EM, Soliz J, Zubieta-Calleja G (2023) COVID-19 Mortality Is Attenuated at High Tropical and Subtropical Altitude: An Observational Study of a Database Covering Five Latin American Countries. Medical Research Archives (online) 11 (8); doi.org/10.18103/mra.v11i8.4299

Kumaraswami K, Arnholdt C, Deindl E, Lasch M. (2023) Rag1 Deficiency Impairs Arteriogenesis in Mice. Int J Mol Sci: 24(16):12839. doi: 10.3390/ijms241612839

Sitaru S, Budke A, Bertini R, Sperandio M. Therapeutic inhibition of CXCR1/2: where do we stand? Intern Emerg Med. 2023 Sep;18(6):1647-1664. doi: 10.1007/s11739-023-03309-5. Epub 2023 May 30. PMID: 37249756; PMCID: PMC10227827.

Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K. The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation.
Immunity. 2023 May 9;56(5):979-997.e11. doi: 10.1016/j.immuni.2023.03.021. Epub 2023 Apr 25. PMID: 37100060.

Jorch SK, McNally A, Berger P, Wolf J, Kaiser K, Chetrusca Covash A, Robeck S, Pastau I, Fehler O, Jauch-Speer SL, Hermann S, Schäfers M, Van Gorp H, Kanneganti A, Dehoorne J, Haerynck F, Penco F, Gattorno M, Chae JJ, Kubes P, Lamkanfi M, Wullaert A, Sperandio M, Vogl T, Roth J, Austermann J. Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever. J Allergy Clin Immunol. 2023 Jul;152(1):230-243. doi: 10.1016/j.jaci.2023.01.037. Epub 2023 Feb 22. PMID: 36822481.

Linder, M. I.; Mizoguchi, Y.; Hesse, S.; Csaba, G.; Tatematsu, M.; Łyszkiewicz, M.; Zietara, N.; Jeske, T.; Hastreiter, M.; Rohlfs, M.; Liu, Y.; Grabowski, P.; Ahomaa, K.; Maier-Begandt, D.; Schwestka, M.; Pazhakh, V.; Isiaku, A.; Briones Miranda, B.; Blombery, P.; Saito, M. K.; Rusha, E.; Alizadeh, Z.; Pourpak, Z.; Kobayashi, M.; Rezaei, N.; Unal, E.; Hauck, F.; Drukker, M.; Walzog, B.; Rappsilber, J.; Zimmer, R.; Lieschke, G. J.; Klein, C. (2023).Human Genetic Defects in SRP19 and SRPRA Cause Severe Congenital Neutropenia with Distinctive Proteome Changes. Blood. 2023 Feb 9;141(6):645-658. PMID: 36223592 DOI: 10.1182/blood.2022016783

Ince LM, Barnoud C, Lutes LK, Pick R, Wang C, Sinturel F, Chen CS, de Juan A, Weber J, Holtkamp SJ, Hergenhan SM, Geddes-McAlister J, Ebner S, Fontannaz P, Meyer B, Vono M, Jemelin S, Dibner C, Siegrist CA, Meissner F, Graw F, Scheiermann C. (2023). Influence of circadian clocks on adaptive immunity and vaccination responses.
Nat Commun. 2023 Jan 30;14(1):476. doi: 10.1038/s41467-023-35979-2. PMID: 36717561

Ma Z, Kessler M, Chelariu-Raicu A, Sperandio M, Mahner S, Jeschke U, von Schönfeldt V. (2023). Sialyl Lewis X mediates interleukin-1 beta induced trophoblast adhesion to endometrial cells during human embryo implantation. Biol Reprod. 2023 Jan 16:ioad007. doi: 10.1093/biolre/ioad007. Online ahead of print. PMID: 36648484

Rohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstätter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M. (2023)
A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny.
JCI Insight. 2023 Jan 12:e155968. doi: 10.1172/jci.insight.155968. Online ahead of print. PMID: 36633909

Bayerl F, Bejarano DA, Bertacchi G, Doffin AC, Gobbini E, Hubert M, Li L, Meiser P, Pedde AM, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml BU, Uderhardt S, Valladeau-Guilemond J, Wilflingseder D, Zaderer V, Böttcher JP. (2023). Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods. Eur J Immunol. 2023 Jan 9:e2249923. doi: 10.1002/eji.202249923. Online ahead of print. PMID: 36623939

2022

Masgrau-Alsina S, Wackerbarth LM, Lim DS, Sperandio M. (2022). MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.Front Immunol. 2022 Dec 23;13:1038936. doi: 10.3389/fimmu.2022.1038936. eCollection 2022. PMID: 36618429

Clausen BE, Amon L, Backer RA, Berod L, Bopp T, Brand A, Burgdorf S, Chen L, Da M, Distler U, Dress RJ, Dudziak D, Dutertre CA, Eich C, Gabele A, Geiger M, Ginhoux F, Giusiano L, Godoy GJ, Hamouda AEI, Hatscher L, Heger L, Heidkamp GF, Hernandez LC, Jacobi L, Kaszubowski T, Kong WT, Lehmann CHK, López-López T, Mahnke K, Nitsche D, Renkawitz J, Reza RA, Sáez PJ, Schlautmann L, Schmitt MT, Seichter A, Sielaff M, Sparwasser T, Stoitzner P, Tchitashvili G, Tenzer S, Tochoedo NR, Vurnek D, Zink F, Hieronymus T. (2022). Guidelines for mouse and human DC functional assays. Eur J Immunol. 2022 Dec 23. doi: 10.1002/eji.202249925. Online ahead of print.
PMID: 36563126.

Probst HC, Stoitzner P, Amon L, Backer RA, Brand A, Chen J, Clausen BE, Dieckmann S, Dudziak D, Heger L, Hodapp K, Hornsteiner F, Hovav AH, Jacobi L, Ji X, Kamenjarin N, Lahl K, Lahmar I, Lakus J, Lehmann CHK, Ortner D, Picard M, Roberti MP, Rossnagel L, Saba Y, Schalla C, Schlitzer A, Schraml BU, Schütze K, Seichter A, Seré K, Seretis A, Sopper S, Strandt H, Sykora MM, Theobald H, Tripp CH, Zitvogel L. (2022). Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues. Eur J Immunol. 2022 Dec 13. doi: 10.1002/eji.202249819. Online ahead of print. PMID: 36512638

Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C. (2022). Dendritic cells direct circadian anti-tumor immune responses. Nature. 2022 Dec 5. doi: 10.1038/s41586-022-05605-0. Online ahead of print. PMID: 36470303

Fischer S, Deindl E. (2022). State of the Art of Innate Immunity-An Overview. Cells. 2022 Aug 30;11(17):2705. doi: 10.3390/cells11172705. PMID: 36078113

Gonzalez Pisfil M, Nadelson I, Bergner B, Rottmeier S, Thomae AW, Dietzel S.(2022).
Stimulated emission depletion microscopy with a single depletion laser using five fluorochromes and fluorescence lifetime phasor separation. Sci Rep. 2022 Aug 18;12(1):14027. doi: 10.1038/s41598-022-17825-5.
PMID: 35982114

Götz P, Azubuike-Osu SO, Braumandl A, Arnholdt C, Kübler M, Richter L, Lasch M, Bobrowski L, Preissner KT, Deindl E. (2022). Cobra Venom Factor Boosts Arteriogenesis in Mice. Int J Mol Sci. 2022 Jul 30;23(15):8454. doi: 10.3390/ijms23158454. PMID: 35955584

Mehari FT, Miller M, Pick R, Bader A, Pekayvaz K, Napoli M, Uhl B, Reichel CA, Sperandio M, Walzog B, Schulz C, Massberg S, Stark K. (2022) .Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states. Sci Signal. 2022 Jul 26;15(744):eabe6909. doi: 10.1126/scisignal.abe6909. Epub 2022 Jul 26. PMID: 35881691

De Virgiliis F, Oliva VM, Kizil B, Scheiermann C. (2022).
Control of lymph node activity by direct local innervation. Trends Neurosci. 2022 Jul 9:S0166-2236(22)00124-2. doi: 10.1016/j.tins.2022.06.006. Online ahead of print. PMID: 35820971 Review.

Ma Z, Yang H, Kessler M, Sperandio M, Mahner S, Jeschke U, von Schönfeldt V. (2022).
Targeting Aberrantly Elevated Sialyl Lewis A as a Potential Therapy for Impaired Endometrial Selection Ability in Unexplained Recurrent Miscarriage. Front Immunol. 2022 Jun 28;13:919193. doi: 10.3389/fimmu.2022.919193. eCollection 2022. PMID: 35837404

Sperandio M. (2022). Commentary on "Failer et al. (2022) Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation" J Clin Invest 2022 (https://doi.org/10.1172/JCI126155).Pflugers Arch. 2022 Jun 28. doi: 10.1007/s00424-022-02723-6. Online ahead of print. PMID: 35764851

Lutz K, Musumeci A, Sie C, Dursun E, Winheim E, Bagnoli J, Ziegenhain C, Rausch L, Bergen V, Luecken MD, Oostendorp RAJ, Schraml BU, Theis FJ, Enard W, Korn T, Krug AB. (2022) Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Nat Commun. 2022 Jun 16;13(1):3456. doi: 10.1038/s41467-022-31054-4. PMID: 35705536

Garnier L, Pick R, Montorfani J, Sun M, Brighouse D, Liaudet N, Kammertoens T, Blankenstein T, Page N, Bernier-Latamani J, Tran NL, Petrova TV, Merkler D, Scheiermann C, Hugues S. (2022) IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis. Sci Adv. 2022 Jun 10;8(23):eabl5162. doi: 10.1126/sciadv.abl5162. Epub 2022 Jun 8. PMID: 35675399

Ishikawa-Ankerhold H, Kroll J, Heuvel DVD, Renkawitz J, Müller-Taubenberger A. (2022) Centrosome Positioning in Migrating Dictyostelium Cells. Cells. 2022 May 29;11(11):1776. doi: 10.3390/cells11111776. PMID: 35681473

Wang C, Lutes LK, Barnoud C, Scheiermann C. (2022) The circadian immune system. Sci Immunol. 2022 Jun 3;7(72):eabm2465. doi: 10.1126/sciimmunol.abm2465. Epub 2022 Jun 3. PMID: 35658012 Review.

Wiechers C, Pezoldt J, Beckstette M, Berner J, Schraml BU, Huehn J. (2022) Lymph node stromal cells support the maturation of pre-DCs into cDC-like cells via colony-stimulating factor 1. Immunology. 2022 May 15. doi: 10.1111/imm.13497. Online ahead of print. PMID: 35569092

Bromberger T, Klapproth S, Sperandio M, Moser M. (2022) Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation. Cells. 2022 May 3;11(9):1532. doi: 10.3390/cells11091532.
PMID: 35563841

Groll T, Silva M, Sarker RSJ, Tschurtschenthaler M, Schnalzger T, Mogler C, Denk D, Schölch S, Schraml BU, Ruland J, Rad R, Saur D, Weichert W, Jesinghaus M, Matiasek K, Steiger K. (2022) Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression.
Cancers (Basel). 2022 Apr 30;14(9):2248. doi: 10.3390/cancers14092248. PMID: 35565377

Depletion of γδ T Cells Leads to Reduced Angiogenesis and Increased Infiltration of Inflammatory M1-like Macrophages in Ischemic Muscle Tissue. Arnholdt C, Kumaraswami K, Götz P, Kübler M, Lasch M, Deindl E. (2022) Cells. 2022 Apr 29;11(9):1490. doi: 10.3390/cells11091490. PMID: 35563796

Müller MB, Hübner M, Li L, Tomasi S, Ließke V, Effinger D, Hirschberger S, Pogoda K, Sperandio M, Kreth S. (2022) Cell-Crossing Functional Network Driven by microRNA-125a Regulates Endothelial Permeability and Monocyte Trafficking in Acute Inflammation. Front Immunol. 2022 Mar 24;13:826047. doi: 10.3389/fimmu.2022.826047. eCollection 2022. PMID: 35401562

Kroll J, Ruiz-Fernandez MJA, Braun MB, Merrin J, Renkawitz J. (2022) Quantifying the Probing and Selection of Microenvironmental Pores by Motile Immune Cells. Curr Protoc. 2022 Apr;2(4):e407. doi: 10.1002/cpz1.407. PMID: 35384410

Molina SA, Maier-Begandt D, Isakson BE, Koval M. Electrophysiological Measurements of Isolated Blood Vessels. Bio Protoc. 2022 Mar 20;12(6):e4359. doi: 10.21769/BioProtoc.4359. PMID: 35434187; PMCID: PMC8983162.

Ma Q, Immler R, Pruenster M, Sellmayr M, Li C, von Brunn A, von Brunn B, Ehmann RK, Wölfel R, Napoli M, Li Q, Romagnani P, Böttcher RT, Sperandio M, Anders HJ, Steiger S.(2022) Soluble uric acid inhibits β2 integrin-mediated neutrophil recruitment in innate immunity. Blood. 2022 Mar 18:blood.2021011234. doi: 10.1182/blood.2021011234. Online ahead of print. PMID: 35303071

Stutte S, Ishikawa-Ankerhold H, Lynch L, Eickhoff S, Nasiscionyte S, Guo C, van den Heuvel D, Setzensack D, Colonna M, Maier-Begandt D, Weckbach L, Brocker T, Schulz C, Walzog B, von Andrian U. (2022) High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue.
J Immunol. 2022 Feb 18:ji2100022. doi: 10.4049/jimmunol.2100022. Online ahead of print. PMID: 35181637

Bader A, Winkelmann M, Forné I, Walzog B, Maier-Begandt D. (2022)
Decoding the signaling profile of hematopoietic progenitor kinase 1 (HPK1) in innate immunity: a proteomic approach.
Eur J Immunol. 2022 Jan 31. doi: 10.1002/eji.202149283. Online ahead of print. PMID: 35099066

Portincasa P, Bonfrate L, Vacca M, De Angelis M, Farella I, Lanza E, Khalil M, Wang DQ, Sperandio M, Di Ciaula A. (2022) Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis.
Int J Mol Sci. 2022 Jan 20;23(3):1105. doi: 10.3390/ijms23031105. PMID: 35163038 Review.

Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, Hinkel R, Hoenig A, Hariharan A, Kim CI, Decker S, Sami H, Koppara T, Oellinger R, Müller OJ, Frank D, Megens R, Nelson P, Weber C, Schnieke A, Sperandio M, Santamaria G, Rad R, Moretti A, Laugwitz KL, Soehnlein O, Ogris M, Kupatt C. (2022) . Endothelial Retargeting of AAV9 In Vivo. Adv Sci (Weinh). 2022 Jan 12:e2103867. doi: 10.1002/advs.202103867. Online ahead of print. PMID: 35023328

2021

Elhag S, Stremmel C, Zehrer A, Plocke J, Hennel R, Keuper M, Knabe C, Winterhalter J, Gölling V, Tomas L, Weinberger T, Fischer M, Liu L, Wagner F, Lorenz M, Stark K, Häcker H, Schmidt-Supprian M, Völker U, Jastroch M, Lauber K, Straub T, Walzog B, Hammer E, Schulz C. (2021) Differences in Cell-Intrinsic Inflammatory Programs of Yolk Sac and Bone Marrow Macrophages. Cells. 2021 Dec 17;10(12):3564. doi: 10.3390/cells10123564. PMID: 34944072

Weckbach LT, Schweizer L, Kraechan A, Bieber S, Ishikawa-Ankerhold H, Hausleiter J, Massberg S, Straub T, Klingel K, Grabmaier U, Zwiebel M, Mann M, Schulz C; EMB Study Group (2021) Association of Complement and MAPK Activation With SARS-CoV-2-Associated Myocardial Inflammation. JAMA Cardiol. 2021 Dec 15. doi: 10.1001/jamacardio.2021.5133. Online ahead of print. PMID: 34910083

Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V. (2021) Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses. Nat Immunol. 2021 Dec;22(12):1563-1576. doi: 10.1038/s41590-021-01064-3. Epub 2021 Nov 22. PMID: 34811541

Elisabeth Deindl and Paul H. A. Quax,(2021) Arteriogenesis and Therapeutic Angiogenesis—An Update. Int. J. Mol. Sci. 2021, 22, 13244. https://doi.org/10.3390/ijms222413244 (Editorial)

Kübler M, Götz P, Braumandl A, Beck S, Ishikawa-Ankerhold H, Deindl E. (2021) Impact of C57BL/6J and SV-129 Mouse Strain Differences on Ischemia-Induced Postnatal Angiogenesis and the Associated Leukocyte Infiltration in a Murine Hindlimb Model of Ischemia. Int J Mol Sci. 2021 Oct 30;22(21):11795. doi: 10.3390/ijms222111795.
PMID: 34769229

Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Mühlstädt M, Boehncke WH, Weber J, Laubender D, Philippou-Massier J, Chen CS, Holtermann L, Vestweber D, Sperandio M, Schraml BU, Halin C, Dibner C, Oster H, Renkawitz J, Scheiermann C. (2021) Circadian clocks guide dendritic cells into skin lymphatics.
Nat Immunol. 2021 Oct 18. doi: 10.1038/s41590-021-01040-x. Online ahead of print.
PMID: 34663979

Lasch, M., Vladymyrov, M., van den Heuvel, D., Götz, P., Deindl, E., Ishikawa-Ankerhold, H. (2021)
Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb
Model. J. Vis. Exp. (175), e62969, doi:10.3791/62969

Bader A, Gao J, Rivière T, Schmid B, Walzog B, Maier-Begandt D.(2021) Molecular Insights Into Neutrophil Biology From the Zebrafish Perspective: Lessons From CD18 Deficiency. Front Immunol. 2021 Sep 7;12:677994. doi: 10.3389/fimmu.2021.677994. eCollection 2021. PMID: 34557186

Salei N, Ji X, Pakalniškytė D, Kuentzel V, Rambichler S, Li N, Moser M, Steiger K, Buch T, Anders HJ, Schraml BU. (2021)
Selective depletion of a CD64-expressing phagocyte subset mediates protection against toxic kidney injury and failure.  Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2022311118. doi: 10.1073/pnas.2022311118. PMID: 34518373

Kübler M, Beck S, Peffenköver LL, Götz P, Ishikawa-Ankerhold H, Preissner KT, Fischer S, Lasch M, Deindl E. (2021) The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia. Int J Mol Sci. 2021 Aug 31;22(17):9484. doi: 10.3390/ijms22179484. PMID: 34502391

Lukacs A, Thomae AW, Krueger P, Schauer T, Venkatasubramani AV, Kochanova NY, Aftab W, Choudhury R, Forne I, Imhof A.(2021) The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila. PLoS Genet. 2021 Aug 23;17(8):e1009744. doi: 10.1371/journal.pgen.1009744. eCollection 2021 Aug. PMID: 34424906

Bromberger T, Klapproth S, Rohwedder I, Weber J, Pick R, Mittmann L, Min-Weißenhorn SJ, Reichel CA, Scheiermann C, Sperandio M, Moser M. (2021) Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking. Front Immunol. 2021 Aug 19;12:702345. doi: 10.3389/fimmu.2021.702345. eCollection 2021.
PMID: 34489950

Arts JJ, Mahlandt EK, Grönloh M, Schimmel L, Noordstra I, Gordon E, van Steen AC, Tol S, Walzog B, van Rijssel J, Nolte MA, Postma M, Khuon S, Heddleston JM, Wait E, Chew TL, Winter M, Montanez E, Goedhart J, van Buul JD. (2021) Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. Elife. 2021 Aug 25;10:e66074. doi: 10.7554/eLife.66074. Online ahead of print. PMID: 34431475

Silvia Fischer and Elisabeth Deindl (2021) Characterization of RNA in Extracellular Vesicles. Appl. Sci. 2021, 11, 7520. https://doi.org/10.3390/app11167520. Review

Yang WH, Westman JS, Heithoff DM, Sperandio M, Cho JW, Mahan MJ, Marth JD. (2021) Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2100937118. doi: 10.1073/pnas.2100937118. PMID: 34266954

Villa R, Jagtap PKA, Thomae AW, Campos Sparr A, Forné I, Hennig J, Straub T, Becker PB. (2021) Divergent evolution toward sex chromosome-specific gene regulation in Drosophila. Genes Dev. 2021 Jul 1;35(13-14):1055-1070. doi: 10.1101/gad.348411.121.. PMID: 34140353

Hinkel R, Batkai S, Bähr A, Bozoglu T, Straub S, Borchert T, Viereck J, Howe A, Hornaschewitz N, Oberberger L, Jurisch V, Kozlik-Feldmann R, Freudenthal F, Ziegler T, Weber C, Sperandio M, Engelhardt S, Laugwitz KL, Moretti A, Klymiuk N, Thum T, Kupatt C (2021) AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction. J Am Coll Cardiol. 2021 Jun 15;77(23):2923-2935. doi: 10.1016/j.jacc.2021.04.028. PMID: 34112319

Chen CS, Weber J, Holtkamp SJ, Ince LM, de Juan A, Wang C, Lutes L, Barnoud C, Kizil B, Hergenhan SM, Salvermoser J, Lasch M, Deindl E, Schraml B, Baumjohann D, Scheiermann C. (2021) Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ. J Exp Med. 2021 Aug 2;218(8):e20202377. doi: 10.1084/jem.20202377. Epub 2021 Jun 4. PMID: 34086056

Götz P, Braumandl A, Kübler M, Kumaraswami K, Ishikawa-Ankerhold H, Lasch M, Deindl E. (2021) C3 Deficiency Leads to Increased Angiogenesis and Elevated Pro-Angiogenic Leukocyte Recruitment in Ischemic Muscle Tissue. Int J Mol Sci. 2021 May 28;22(11):5800. doi: 10.3390/ijms22115800. PMID: 34071589

Henneke P, Kierdorf K, Hall LJ, Sperandio M, Hornef M. (2021) Perinatal development of innate immune topology. Elife. 2021 May 25;10:e67793. doi: 10.7554/eLife.67793. PMID: 34032570 Review

Uhl B, A Mittmann L, Dominik J, Hennel R, Smiljanov B, Haring F, B Schaubächer J, Braun C, Padovan L, Pick R, Canis M, Schulz C, Mack M, Gutjahr E, Sinn P, Heil J, Steiger K, Kanse SM, Weichert W, Sperandio M, Lauber K, Krombach F, Reichel CA. (2021) uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils. EMBO Mol Med. 2021 May 16:e13110. doi: 10.15252/emmm.202013110. Online ahead of print.PMID: 33998175

Morikis VA, Hernandez AA, Magnani JL, Sperandio M, Simon SI. (2021) Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients. Front Immunol. 2021 Apr 28;12:663886. doi: 10.3389/fimmu.2021.663886. eCollection 2021. PMID: 33995392 Review

Stutte S, Ruf J, Kugler I, Ishikawa-Ankerhold H, Parzefall A, Marconi P, Maeda T, Kaisho T, Krug A, Popper B, Lauterbach H, Colonna M, von Andrian U, Brocker T. (2021) Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain Behav Immun. 2021 Apr 22:S0889-1591(21)00176-8. doi: 10.1016/j.bbi.2021.04.018. Online ahead of print.
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Hager L, Averbeck B, Voelcker-Rehage C, Kutz D (2021). Sex differences in the consumption of over-the-counter analgesics among amateur volleyball players. BMC Sports Sci Med Rehabil. 2021 Apr 29;13(1):45. doi: 10.1186/s13102-021-00273-5. PMID: 33910635

Immler R, Nadolni W, Bertsch A, Morikis V, Rohwedder I, Masgrau-Alsina S, Schroll T, Yevtushenko A, Soehnlein O, Moser M, Gudermann T, Barnea ER, Rehberg M, Simon SI, Zierler S, Pruenster M, Sperandio M. (2021) The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation. Cardiovasc Res. 2021 Apr 21:cvab133. doi: 10.1093/cvr/cvab133. Online ahead of print.
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Maier-Begandt D, Comstra HS, Molina SA, Krüger N, Ruddiman CA, Chen YL, Chen X, Biwer LA, Johnstone SR, Lohman AW, Good ME, DeLalio LJ, Hong K, Bacon HM, Yan Z, Sonkusare SK, Koval M, Isakson BE. A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability. Sci Signal. 2021 Mar 2;14(672):eaba2940. doi: 10.1126/scisignal.aba2940. PMID: 33653920; PMCID: PMC8011850.

Abdel Rahman F, d'Almeida S, Zhang T, Asadi M, Bozoglu T, Bongiovanni D, von Scheidt M, Dietzel S, Schwedhelm E, Hinkel R, Laugwitz KL, Kupatt C, Ziegler T. (2021) Sphingosine-1-Phosphate Attenuates Lipopolysaccharide-Induced Pericyte Loss via Activation of Rho-A and MRTF-A. Thromb Haemost. 2021 Mar;121(3):341-350. doi: 10.1055/s-0040-1716844. Epub 2020 Oct 4. PMID: 33011963

Matthias Kübler, Sebastian Beck, Silvia Fischer, Philipp Götz, Konda Kumaraswami, Hellen Ishikawa-Ankerhold, Manuel Lasch, and Elisabeth Deindl (2021). Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines 2021, 9, 395. https://doi.org/10.3390/biomedicines9040395

Nadolni W, Immler R, Hoelting K, Fraticelli M, Ripphahn M, Rothmiller S, Matsushita M, Boekhoff I, Gudermann T, Sperandio M and Zierler S. (2021). TRPM7 Kinase is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling. Front. Immunol. 11:606893. doi: 10.3389/fimmu.2020.606893

Andreas Margraf, Markus Sperandio (2021). Leukocyte Trafficking and Hemostasis in the Mouse Fetus in vivo: A Practical Guide. Front Cell Dev Biol. Jan 21;8:632297. doi: 10.3389/fcell.2020.632297. eCollection 2020.

Papaioannou, NE, Salei N, Rambichler S, Ravi K, Popovic J, Küntzel V, Lehmann CHK, Fiancette R, Salvermoser J, Gajdasik DW, Mettler R, Messerer D, Carrelha J, Ohnmacht C, Haller D, Stumm R, Straub T, Jacobsen SEW, Schulz C, Withers DR, Schotta G, Dudziak D, Schraml BU. (2021). Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice. Nature Communications 21, 464.

Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A. (2021)
Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation.
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2020

Immler R, Lange-Sperandio B, Steffen T, Beck H, Rohwedder I, Roth J, Napoli M, Hupel G, Pfister F, Popper B, Uhl B, Mannell H, Reichel CA, Vielhauer V, Scherberich J, Sperandio M, Pruenster M. (2020)
Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo.
Front Immunol. 2020 Dec 22;11:588245. doi: 10.3389/fimmu.2020.588245. eCollection 2020. PMID: 33414784

Preissner KT, Fischer S, Deindl E. (2020). Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection.
J Immunol. 2020 Dec 11:ji2000807. doi: 10.4049/jimmunol.2000807. Online ahead of print.
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Orosz A, Walzog B, Mócsai A. (2020). In Vivo Functions of Mouse Neutrophils Derived from HoxB8-Transduced Conditionally Immortalized Myeloid Progenitors.
J Immunol. 2020 Dec 11:ji2000807. doi: 10.4049/jimmunol.2000807. Online ahead of print.
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Lasch M, Kumaraswami K, Nasiscionyte S, Kircher S, van den Heuvel D, Meister S, Ishikawa-Ankerhold H, Deindl E. (2020). RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue. .
Front Physiol. 2020 Nov 6;11:576736. doi: 10.3389/fphys.2020.576736. eCollection 2020. PMID: 33240100

Rivière T, Bader A, Pogoda K, Walzog B, Maier-Begandt D. (2020) Structure and Emerging Functions of LRCH Proteins in Leukocyte Biology. Front Cell Dev Biol. 2020 Sep 22;8:584134. doi: 10.3389/fcell.2020.584134. eCollection 2020. PMID: 33072765 Review

Kameritsch P, Renkawitz J (2020) Principles of Leukocyte Migration Strategies. Trends in Cell Biology. doi: 10.1016/j.tcb.2020.06.007.

Deindl E, Quax PHA. Arteriogenesis and Therapeutic Angiogenesis in Its Multiple Aspects.Cells. 2020 Jun 10;9(6):E1439. doi: 10.3390/cells9061439. PMID: 32531915

Kopf A, Renkawitz J, Hauschild R, Girkontaite I, Tedford K, Merrin J, Thorn-Seshold O, Trauner D, Häcker H, Fischer KD, Kiermaier E, Sixt M. Microtubules control cellular shape and coherence in amoeboid migrating cells. J Cell Biol. 2020 Jun 1;219(6):e201907154. doi: 10.1083/jcb.201907154.

Elisabeth Deindl and Paul H. A. Quax. From Increased Fluid Shear Stress to Natural Bypass Growth. Int. J. Mol. Sci. 2020 May, 21, 3707; doi:10.3390/ijms21103707

Masgrau-Alsina S, Sperandio M, Rohwedder I. Neutrophil recruitment and intracellular vesicle transport: A short overview. Eur J Clin Invest. 2020 Jun;50(6):e13237. doi: 10.1111/eci.13237. Epub 2020 May 6. PMID: 32289185 Review.

Konda Kumaraswami, Natallia Salei, Sebastian Beck, Stephan Rambichler, Anna-Kristina Kluever, Manuel Lasch, Lisa Richter, Barbara U Schraml, Elisabeth Deindl. A Simple and Effective Flow Cytometry-Based Method for Identification and Quantification of Tissue Infiltrated Leukocyte Subpopulations in a Mouse Model of Peripheral Arterial Disease. Int J Mol Sci. 2020 May 19;21(10):E3593.
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Sitte S, Doehler D, Sperandio M, Marth JD, Voehringer D. The sialyltransferase ST3Gal-IV guides murine T-cell progenitors to the thymus. Blood Adv. 2020 May 12;4(9):1930-1941. doi: 10.1182/bloodadvances.2019001046. PMID: 32380539 Free PMC article.

Lasch M, Caballero Martinez A, Kumaraswami K, Ishikawa-Ankerhold H, Meister S, Deindl E (2020) Contribution of the potassium channels KV1.3 and KCa3.1 to smooth muscle cell proliferation in growing collateral arteries. Cells:9,913 doi:10.3390/cells9040913

Tamás Németh, Markus Sperandio and Attila Mócsai. Neutrophils as emerging therapeutic targets. Nat Rev Drug Discov (2020). https://doi.org/10.1038/s41573-019-0054-z

Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis and Vasileia Ismini Alexaki (2020). DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1. 2020/01/24/jimmun J Immunol published online 24 January 2020 

Salei N, Rambichler S, Salvermoser J, Papaioannou NE, Schuchert R, Pakalniškytė D, Li N, Marschner JA, Lichtnekert J, Stremmel C, Cernilogar FM, Salvermoser M, Walzog B, Straub T, Schotta G, Anders HJ, Schulz C, Schraml BU (2020). The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties. J Am Soc Nephrol. 2020 Jan 13. pii: ASN.2019040419. doi: 10.1681/ASN.2019040419 [Epub ahead of print]