Selected Publications
Publications (selection; for a complete list refer to https://orcid.org/0000-0002-7689-3613)
Napoli M, Immler R, Rohwedder I, Lupperger V, Pfabe J, Gonzalez Pisfil M, Yevtushenko A, Vogl T, Roth J, Salvermoser M, Dietzel S, Rupnik MS, Marr C, Walzog B, Sperandio M, Pruenster M. Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment. Elife. 2024 Dec 19;13:RP96810. doi: 10.7554/eLife.96810.
Immler R., Nussbaumer K, Doerner A, El Bounkari O, Huber S, Abisch J, Napoli M, Klapproth S, Margraf A, Pruenster M, Rohwedder I, Lange-Sperandio B, Mall MA, De Jong R, Ohnmacht C, Bernhagen J, Voehringer D, Marth JD, Frommhold D, Sperandio M. CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV. Proc Natl Acad Sci 2024; 121(19):e2319057121
Rohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstatter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M. A20 and the noncanonical NF-kappaB pathway are key regulators of neutrophil recruitment during fetal ontogeny. JCI Insight. 2023 Feb 22;8(4). Epub 20230222.
GNPI PRIZE 2023 for Ina Rohwedder and Lou Wackerbarth
Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nat Immunol. 2023 Oct 30. Epub 20231030.
Immler R, Nadolni W, Bertsch A, Morikis V, Rohwedder I, Masgrau-Alsina S, Schroll T, Yevtushenko A, Soehnlein O, Moser M, Gudermann T, Barnea ER, Rehberg M, Simon SI, Zierler S, Pruenster M, Sperandio M. The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation. Cardiovasc Res. 2022 Mar 25;118(5):1289-1302.
Henneke P, Kierdorf K, Hall L, Sperandio M, Hornef M. Perinatal development of innate immune topology. Elife. 2021 5/25/2021;10. REVIEW
Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A. Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation. Immunity. 2021 3/9/2021;54(3):468-483.
Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Mühlstädt M, Boehncke WH, Weber J, Laubender D, Philippou-Massier J, Chen CS, Holtermann L, Vestweber D, Sperandio M, Schraml BU, Halin C, Dibner C, Oster H, Renkawitz J, Scheiermann C. Circadian clocks guide dendritic cells into skin lymphatics. Nat Immunol. 2021 11/2021;22(11):1375-1381.
Nemeth T, Sperandio M, Mocsai A. Neutrophils as emerging therapeutic targets. Nat Rev Drug Discov. 2020 4/2020;19(4):253-275. REVIEW
Margraf A, Nussbaum C, Sperandio M. Ontogeny of platelet function. Blood Adv. 2019 2/26/2019;3(4):692-703. REVIEW
Margraf A, Nussbaum C, Rohwedder I, Klapproth S, Kurz ARM, Florian A, Wiebking V, Pircher J, Pruenster M, Immler R, Dietzel S, Kremer L, Kiefer F, Moser M, Flemmer AW, Quackenbush E, von Andrian UH, Sperandio M. Maturation of Platelet Function During Murine Fetal Development In Vivo. Arterioscler Thromb Vasc Biol. 2017 6/2017;37(6):1076-1086.
GNPI PRIZE 2019 to Andreas Margraf and Claudia Nussbaum
Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD. Recurrent infection progressively disables host protection against intestinal inflammation. Science. 2017 12/22/2017;358(6370).
Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schafer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest. 2016 11/1/2016;126(11):4125-4139.
SERVIER AWARD 2017 European Society of Microcirculation to Angela Kurz
Pruenster M, Kurz AR, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leanderson T, Chavakis T, Roth J, Vogl T, Sperandio M. Extracellular MRP8/14 is a regulator of beta2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun. 2015 2015;6:6915.
Nussbaum C, Bannenberg S, Keul P, Graler MH, Goncalves-de-Albuquerque CF, Korhonen H, von Wnuck LK, Heusch G, HC dCFN, Rohwedder I, Gothert JR, Prasad VP, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun. 2015 2015;6:6416.
SERVIER AWARD 2015 European Society of Microcirculation to Claudia Nussbaum und Sarah Bannenberg
Sperandio M, Quackenbush EJ, Sushkova N, Altstätter J, Nussbaum C, Schmid S, Pruenster M, Kurz A, Margraf A, Steppner A, Schweiger N, Borsig L, Boros I, Krajewski N, Genzel-Boroviczeny O, Jeschke U, Frommhold D, von Andrian UH. Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels. Blood 2013 May 23; 121(21):e118-128.
Yang WH, Nussbaum C, Grewal PK, Marth JD, Sperandio M. Coordinated Roles of ST3Gal-VI and ST3Gal-IV Sialyltransferases in the Synthesis of Selectin Ligands. Blood 2012 August 2; 120 (5):1015-1026.
Frommhold D, Kamphues A, Mannigel I, Pruenster M, Lukic IK, Socher I, Zablotskaya V, Buschmann K, Lange-Sperandio B, Schymeinsky J, Ryschich E, Poeschl J, Kupatt C, Nawroth P, Walzog B, Bierhaus A, Sperandio M. RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood 2010 August 5; 116(5):841-9.
Sperandio M, Gleissner CA, Ley K. Glycosylation in immune cell trafficking. Immunol Rev. 2009 2009;230:97-113. REVIEW
Frommhold D, Ludwig A, Bixel MG, Zarbock A, Babushkina I, Weissinger M, Cauwenberghs S, Ellies LG, Marth JD, Beck-Sickinger AG, Sixt M, Lange-Sperandio B, Zernecke A, Brandt E, Weber C, Vestweber D, Ley K, Sperandio M. Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J Exp Med 2008 June 9; 205(6):1435-46.
Sperandio M, M.L. S, Forlow SB, Olson TS, Xia L, McEver RP, Ley K. P-selectin Glycoprotein Ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J Exp Med. 2003 2003;197(10):1355-1363.
Sperandio M, Thatte A, Foy D, Ellies LG, Marth JD, Ley K. Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice. Blood. 2001 6/15/2001;97(12):3812-3819.
Pries AR, Secomb TW, Gessner T, Sperandio M, Gross JF, Gaehtgens P. Resistance to blood flow in microvessels in vivo. Circ Res. 1994 1994;75:904-9