Selected Publications

Kübler M, Beck S, Peffenköver LL, Götz P, Ishikawa-Ankerhold H, Preissner KT, Fischer S, Lasch M, Deindl E. (2021) The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia. Int J Mol Sci. 2021 Aug 31;22(17):9484. doi: 10.3390/ijms22179484. PMID: 34502391

Chen CS, Weber J, Holtkamp SJ, Ince LM, de Juan A, Wang C, Lutes L, Barnoud C, Kizil B, Hergenhan SM, Salvermoser J, Lasch M, Deindl E, Schraml B, Baumjohann D, Scheiermann C. (2021) Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ. J Exp Med. 2021 Aug 2;218(8):e20202377. doi: 10.1084/jem.20202377. Epub 2021 Jun 4. PMID: 34086056

Götz P, Braumandl A, Kübler M, Kumaraswami K, Ishikawa-Ankerhold H, Lasch M, Deindl E. (2021) C3 Deficiency Leads to Increased Angiogenesis and Elevated Pro-Angiogenic Leukocyte Recruitment in Ischemic Muscle Tissue. Int J Mol Sci. 2021 May 28;22(11):5800. doi: 10.3390/ijms22115800. PMID: 34071589

Matthias Kübler, Sebastian Beck, Silvia Fischer, Philipp Götz, Konda Kumaraswami, Hellen Ishikawa-Ankerhold, Manuel Lasch, and Elisabeth Deindl (2021). Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines 2021, 9, 395. https://doi.org/10.3390/biomedicines9040395

Preissner KT, Fischer S, Deindl E. (2020). Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection.
J Immunol. 2020 Dec 11:ji2000807. doi: 10.4049/jimmunol.2000807. Online ahead of print.
PMID: 33310871

Lasch M, Kumaraswami K, Nasiscionyte S, Kircher S, van den Heuvel D, Meister S, Ishikawa-Ankerhold H, Deindl E. (2020). RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue. .
Front Physiol. 2020 Nov 6;11:576736. doi: 10.3389/fphys.2020.576736. eCollection 2020. PMID: 33240100

Deindl E, Quax PHA. Arteriogenesis and Therapeutic Angiogenesis in Its Multiple Aspects. Cells. 2020 Jun 10;9(6):E1439. doi: 10.3390/cells9061439. PMID: 32531915

Elisabeth Deindl and Paul H. A. Quax. From Increased Fluid Shear Stress to Natural Bypass Growth. Int. J. Mol. Sci. 2020 May, 21, 3707; doi:10.3390/ijms21103707

Kluever AK, Braumandl A, Fischer S, Preissner KT, Deindl E. The Extraordinary Role of Extracellular RNA in Arteriogenesis, the Growth of Collateral Arteries. Int J Mol Sci. 2019 Dec 7;20(24):6177. doi: 10.3390/ijms20246177. PMID: 31817879 Free PMC article. Review.

Lasch M, Kleinert EC, Meister S, Kumaraswami K, Buchheim JI, Grantzow T, Lautz T, Salpisti S, Fischer S, Troidl K, Fleming I, Randi AM, Sperandio M, Preissner KT, Deindl E. Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice. Blood. 2019 Oct 24;134(17):1469-1479. doi: 10.1182/blood.2019001392. PMID: 31501155

Wagner M, Mahlmann A, Deindl E, Zuschratter W, Riek-Burchardt M, Kostin S, Luani B, Baer C, Youssef A, Herold J.
Clinical improvement and enhanced collateral vessel growth after xenogenic monocyte transplantation. Am J Transl Res. 2019 Jul 15;11(7):4063-4076. eCollection 2019. PMID: 31396318 Free PMC article.

Thulasingam S, Krishnasamy S, Raj C D, Lasch M, Vedantham S, Deindl E. Insulin Treatment Forces Arteriogenesis in Diabetes Mellitus by Upregulation of the Early Growth Response-1 (Egr-1) Pathway in Mice. Int J Mol Sci. 2019 Jul 5;20(13):3320. doi: 10.3390/ijms20133320. PMID: 31284541 Free PMC article.

Konda Kumaraswami, Natallia Salei, Sebastian Beck, Stephan Rambichler, Anna-Kristina Kluever, Manuel Lasch, Lisa Richter, Barbara U Schraml, Elisabeth Deindl. A Simple and Effective Flow Cytometry-Based Method for Identification and Quantification of Tissue Infiltrated Leukocyte Subpopulations in a Mouse Model of Peripheral Arterial Disease. Int J Mol Sci. 2020 May 19;21(10):E3593. doi: 10.3390/ijms21103593.

Lasch M, Nekolla K, Klemm AH, Buchheim JI, Pohl U, Dietzel S, Deindl E. Estimating hemodynamic shear stress in murine peripheral collateral arteries by two-photon line scanning. Mol Cell Biochem. 2019 Mar;453(1-2):41-51. doi: 10.1007/s11010-018-3430-9. Epub 2018 Aug 20. PMID: 30128948

Lasch M, Caballero Martinez A, Kumaraswami K, Ishikawa-Ankerhold H, Meister S, Deindl E (2020) Contribution of the potassium channels KV1.3 and KCa3.1 to smooth muscle cell proliferation in growing collateral arteries. Cells:9,913 doi:10.3390/cells9040913

Elsemüller AK, Tomalla V, Gärtner U, Troidl K, Jeratsch S, Graumann J, Baal N, Hackstein H, Lasch M, Deindl E, Preissner KT, Fischer S. (2019) Characterization of mast cell-derived rRNA-containing microvesicles and their inflammatory impact on endothelial cells. FASEB J:33(4):5457-5467 doi: 10.1096/fj.201801853RR

Kluever AK, Deindl E. (2018) Extracellular RNA, a Potential Drug Target for Alleviating Atherosclerosis, Ischemia/Reperfusion Injury and Organ Transplantation. Curr Pharm Biotechnol:19(15):1189-1195 doi: 10.2174/1389201020666190102150610

Kluever AK, Deindl E. (2018) Extracellular Nucleic Acids in Health and Disease. Curr Pharm Biotechnol:19(15):1180-1181 doi: 10.2174/138920101915190125142421

Deindl E. (2018) Midkine controls natural bypass growth by regulating the bioavailability of VEGF. In: Atlas of Science; http://atlasofscience.org

Vedantham S, Kluever AK, Deindl E. (2018) Is there a Chance to Promote Arteriogenesis by DPP4 Inhibitors Even in Type 2 Diabetes? A Critical Review. Cells doi: 10.3390/cells7100181

Weckbach LT, Preissner KT, Deindl E. (2018) The Role of Midkine in Arteriogenesis Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation. Int J Mol Scidoi: 10.3390/ijms19092559

Lasch M, Nekolla K, Klemm AH, Buchheim JI, Pohl U, Dietzel S, Deindl E.(2018) Estimating hemodynamic shear stress in murine peripheral collateral arteries by two-photon line scanning. Mol Cell Biochem doi: 10.1007/s11010-018-3430-9

Buchheim JI, Hoskyns S, Moser D, Han B, Deindl E, Hörl M, Biere K, Feuerecker M, Schelling G, Choukèr A. (2018) Oxidative burst and Dectin-1-triggered phagocytosis affected by norepinephrine and endocannabinoids: implications for fungal clearance under stress. Int Immunol:30(2):79-89

Lautz T, Lasch M, Borgolte J, Troidl K, Pagel JI, Caballero-Martinez A, Kleinert EC, Walzog B, Deindl E. (2018) Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3. EBioMedicine:27:237-246

Kirsch J, Schneider H, Pagel JI, Rehberg M, Singer M, Hellfritsch J, Chillo O, Schubert KM, Qiu J, Pogoda K, Kameritsch P, Uhl B, Pircher J, Deindl E, Müller S, Kirchner T, Pohl U, Conrad M, Beck H. Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1891-9. doi: 10.1161/ATVBAHA.116.307843. Epub 2016 Jul 7. PMID: 27386940

Chillo O, Kleinert EC, Lautz T, Lasch M, Pagel JI, Heun Y, Troidl K, Fischer S, Caballero-Martinez A, Mauer A, Kurz AR, Assmann G, Rehberg M, Kanse SM, Nieswandt B, Walzog B, Reichel CA, Mannell H, Preissner KT, Deindl E. Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function.Cell Rep. 2016 Aug 23;16(8):2197-207.doi: 10.1016/j.celrep.2016.07.040. Epub 2016 Aug 11. PMID: 27524614

Lasch M, Caballero-Martinez A, Troidl K, Schloegl I, Lautz T, Deindl E. Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation. Lab Invest. 2016 Aug;96(8):830-8. doi: 10.1038/labinvest.2016.62. Epub 2016 May 30. PMID: 27239731

Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. J Am Heart Assoc. 2016 Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429.

Trenkwalder T, Deindl E, Bongiovanni D, Lee S, Schunkert H, Kupatt C, Hinkel R. Thymosin-β4-mediated therapeutic neovascularization: role of the PI3K/AKT pathway. Expert Opin Biol Ther. 2015; 15 Suppl 1:S175-85

Chandraratne S, von Bruehl ML, Pagel JI, Stark K, Kleinert E, Konrad I, Farschtschi S, Coletti R, Gärtner F, Chillo O, Legate KR, Lorenz M, Rutkowski S, Caballero-Martinez A, Starke R, Tirniceriu A, Pauleikhoff L, Fischer S, Assmann G, Mueller-Hoecker J, Ware J, Nieswandt B, Schaper W, Schulz C, Deindl E, Massberg S. Critical role of platelet glycoprotein ibα in arterial remodeling. Arterioscler Thromb Vasc Biol. 2015; 35(3):589-97

Faber JE, Chilian WM, Deindl E, van Royen N, Simons M. A Brief Etymology of the Collateral Circulation. Arterioscler Thromb Vasc Biol. 2014 Jul 10; pii: ATVBAHA.114.303929.

Deindl E. Mechanistic insights into the functional role of vascular endothelial growth factor and its signalling partner brain-derived neurotrophic factor in angiogenic tube formation. Acta Physiol (Oxf). 2014 Jun; 211(2):268-70

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun. 2014 Jun 9; 5:3970

Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Müller-Höcker J, Deindl E, Sperandio M, Walzog B. (2014) The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ß2 integrins (CD11/CD18). Blood 2014 Mar 20; 123(12):1887-96

Qin D, Trenkwalder T, Lee S, Chillo O, Deindl E, Kupatt C, Hinkel R. Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. PLoS One. 2013 Apr 16; 8(4):e61831

Li YY, Yuece B, Cao HM, Lin HX, Lv S, Chen JC, Ochs S, Sibaev A, Deindl E, Schaefer C, Storr M. Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis. Lab Invest. 2013 Mar; 93(3):322-33

Deindl E, Schaper W. Editorial: avenue to arteriogenesis. Curr Vasc Pharmacol. 2013 Jan; 11(1):2-4

Pagel JI, Deindl E. Disease progression mediated by egr-1 associated signaling in response to oxidative stress. Int J Mol Sci. 2012 Oct 12; 13(10):13104-1

Fischer S, Grantzow T, Pagel JI, Tschernatsch M, Sperandio M, Preissner KT, Deindl E. Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines. Thromb Haemost. 2012 Oct; 108(4):730-41.

Weckbach LT, Groesser L, Borgolte J, Pagel JI, Pogoda F, Schymeinsky J, Müller-Höcker J, Shakibaei M, Muramatsu T, Deindl E, Walzog B. Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis. Am J Physiol Heart Circ Physiol. 2012 Aug 15; 303(4):H429-38

Pagel JI, Ziegelhoeffer T, Heil M, Fischer S, Fernández B, Schaper W, Preissner KT, Deindl E. Role of early growth response 1 in arteriogenesis: impact on vascular cell proliferation and leukocyte recruitment in vivo. Thromb Haemost. 2012 Mar; 107(3):562-74